Reliable routine method for determination of perazine in serum by thin-layer chromatography with an internal standard

The use of a high-performance thin-layer chromatography linear chamber and of thioridazine as internal standard increases the performance of thin-layer chromatography (TLC) with direct densitometric scanning, and allows the rapid determination of serum levels of the neuroleptic drug perazine under usual therapeutic conditions. TLC is superior to gas—liquid chromatography in so far as the main metabolite desmethylperazine can be easily separated and detected by the same procedure.