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Genetic variation in alkaline phosphatase of the house mouse (Mus musculus) with emphasis on a manganese-requiring isozyme |
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| Authors: | Frank H. Wilcox Lisa Hirschhorn Benjamin A. Taylor James E. Womack Thomas H. Roderick |
| Affiliation: | 1. Life Sciences Department, Indiana State University, 47809, Terre Haute, Indiana 2. 29 Washington Square, 10011, New York, New York 3. The Jackson Laboratory, 04609, Bar Harbor, Maine 4. Department of Veterinary Pathology, Institute of Comparative Medicine, Texas A. and M. University, 77843, College Station, Texas |
| Abstract: | Genetic variation among inbred strains is described for electrophoretic migration of alkaline phosphatase from intestine, kidney, blood plasma, and three isozymes of liver. A manganese-requiring isozyme of liver and kidney unaffected by neuraminidase is described, and the locus controlling variation in this isozyme is designated Akp-1. Data from recombinant inbred strains place the locus on chromosome 1 at a distance of 3.6 +/- 2.9 cM from the M1s locus on the side distal to the centromere. Test-cross data show the following gene order and recombination percentages: Dip-1 19.0 +/- 3.8% Lp 7.4 +/- 2.2% Akp-1. |
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