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Surface-Binding to Cardiolipin Nanodomains Triggers Cytochrome c Pro-apoptotic Peroxidase Activity via Localized Dynamics
Authors:Mingyue Li  Abhishek Mandal  Vladimir A. Tyurin  Maria DeLucia  Jinwoo Ahn  Valerian E. Kagan  Patrick C.A. van der Wel
Affiliation:1. Department of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA;2. Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15213, USA;3. Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15213, USA;4. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA;5. Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15213, USA;6. Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15213, USA;7. Laboratory of Navigational Redox Lipidomics, IM Sechenov Moscow State Medical University, Moscow 119146, Russian Federation;8. Zernike Institute for Advanced Materials, University of Groningen, 9747 AG Groningen, The Netherlands
Abstract:
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  • Keywords:cardiolipin  mitochondrial protein  apoptosis  membrane protein  PUFA  protein structure and dynamics  membrane oxidation  lipidomics  solid-state NMR
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