Synthesized esters of ferulic acid induce release of cytochrome c from rat testes mitochondria |
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Authors: | E. Cione P. Tucci V. Senatore M. Perri S. Trombino F. Iemma N. Picci G. Genchi |
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Affiliation: | (1) Dipartimento Farmaco-Biologico, Laboratorio di Biochimica, Edificio Polifunzionale, Università della Calabria, 87036 Rende, CS, Italy;(2) Dipartimento di Scienze Farmaceutiche, Laboratorio di Chimica Organica, Edificio Polifunzionale, Università della Calabria, 87036 Rende, CS, Italy |
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Abstract: | Ferulic acid plays a chemopreventive role in cancer by inducing tumor cells apoptosis. As mitochondria play a key role in the induction of apoptosis in many cells types, here we investigate the mitochondrial permeability transition (MPT) and the release of cytochrome c induced by ferulic acid and its esters in rat testes mitochondria, in TM-3 and MLTC-1 cells. While ferulic acid, but not its esters, induced MPT and cytochrome c release in rat testes isolated mitochondria, in TM-3 cells we found that both ferulic acid and its esters induced cytochrome c release from mitochondria in a dose-dependent manner, suggesting a potential target of these compounds in the induction of cell apoptosis. The apoptosis induced by ferulic acid is therefore associated with the mitochondrial pathway involving cytochrome c release and caspase-3 activation. Cione and Tucci have equally contributed to this article. |
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Keywords: | Ferulic acid Cytochrome c Apoptosis Mitochondria TM-3 cells MLTC-1 cells |
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