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Lateral diffusion of membrane lipids and proteins is increased specifically in neurites of differentiating neuroblastoma cells |
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| Authors: | S W de Laat P T van der Saag E L Elson J Schlessinger |
| Abstract: | Lateral diffusion of membrane lipids and proteins was determined in differentiating C1300 mouse neuroblastoma cells by fluorescence photo-bleaching recovery measurements. It is demonstrated that upon differentiation the lateral diffusion of membrane lipids and proteins is increased specifically in the extending neurites. This indicates the appearance of a topographical heterogeneity in the cell membrane, whereby more fluid domains become located in the membrane of the neurites. |
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