The effect of natural dicarbonyls on activity of antioxidant enzymes in vitro and in vivo |
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Authors: | V Z Lankin G G Konovalova A K Tikhaze L V Nedosugova |
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Institution: | 1.Russian Cardiology Research Complex,Moscow,Russia |
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Abstract: | Natural dicarbonyls, which may be accumulated during oxidative stress in atherosclerosis (e.g. malondialdehyde) or carbonyl
stress in diabetes mellitus (glyoxal and methylglyoxal) effectively inhibited activities of commercial preparations of the
antioxidant enzymes: Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and Se-contained glutathione peroxidase from human and bovine
erythrocytes, and also rat liver glutathione-S-transferase. After incubation of human erythrocytes with 10 mM of each investigated
dicarbonyls the decrease of intracellular Cu,Zn-SOD was observed. The decreased activity of erythrocyte Cu,Zn-SOD was also
detected in patients with diabetes mellitus type 2 with carbohydrate metabolism impairments but effective sugar-lowered therapy
was accompanied by the increase of this enzyme activity. The increase of erythrocytes Cu,Zn-SOD activity in diabetic patients
treated with metformin (which may utilize methylgly-oxal) was higher than in erythrocytes of diabetic patients subjected to
traditional therapy. |
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