An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis |
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| Authors: | David D McErlain Veronica Ulici Mark Darling Joseph S Gati Vasek Pitelka Frank Beier David W Holdsworth |
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| Institution: | (1) Department of Medical Biophysics; Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street, London, ON, Canada, N6A 3K7;(2) Imaging Research Laboratories, Robarts Research Institute; Schulich School of Medicine and Dentistry, The University of Western Ontario, 100 Perth Drive, London, ON, Canada, N6A 5K8;(3) Department of Physiology & Pharmacology; Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street, London, ON, Canada, N6A 3K7;(4) Department of Pathology; Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street, London, ON, Canada, N6A 3K7;(5) Department of Surgery; Schulich School of Medicine and Dentistry, The University of Western Ontario, 1151 Richmond Street, London, ON, N6A 3K7, Canada |
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| Abstract: | Introduction Subchondral bone cysts (SBC) have been identified in patients with knee osteoarthritis (OA) as a cause of greater pain, loss
of cartilage and increased chance of joint replacement surgery. Few studies monitor SBC longitudinally, and clinical research
using three-dimensional imaging techniques, such as magnetic resonance imaging (MRI), is limited to retrospective analyses
as SBC are identified within an OA patient cohort. The purpose of this study was to use dual-modality, preclinical imaging
to monitor the initiation and progression of SBC occurring within an established rodent model of knee OA. |
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