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A novel strategy to inhibit the reproduction and translation of hepatitis C virus
Authors:AiPing Duan  LiMin Ning  Chao Li  YaFei Hou  NaNa Yang  LiZhou Sun  GenXi Li
Institution:14468. Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China
24468. Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai, 200444, China
34468. Department of Obstetrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210036, China
Abstract:Hepatitis C virus (HCV), a positive single-stranded RNA virus, is a major cause of liver disease in humans. Herein we report a novel strategy to inhibit the reproduction and translation of HCV using a short RNA, named an Additional RNA, to activate the endonuclease activity of Argonaute 2 (Ago2). In the presence of the Additional RNA, the HCV genome RNA has the requisite 12 nucleotides of base-pairing with microRNA-122. This activates the endonuclease activity of Ago2, resulting in cleavage and release of the HCV genome RNA from Ago2 and microRNA-122. The free HCV genome RNA would be susceptible to intracellular degradation, effectively inhibiting its reproduction and translation. This study presents a new method to inhibit HCV that may hold great potential for HCV treatment in the future.
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