Phe and Asn side chains in DNA double strands |
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| Authors: | Diederichsen U Biro C M |
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| Institution: | Institut für Organische Chemnie, Universit?t Würzburg, Germany. diederichsen@chemie.uni-wuerzburg.de |
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| Abstract: | The contribution of amino acid side chains to the recognition of DNA by peptides or proteins is evaluated by substituting single nucleobases of a DNA double strand by amino acid side chains. C-nucleosides with the side chains of phenylalanine and asparagine were synthesized and incorporated in DNA. This modification should allow to keep the double strand conformation. Hydrogen bonds, pi-pi-interactions and solvation have an influence on the double strand stability. |
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