Decreased Cerebrospinal Fluid Glutamine Levels in Patients with Benign Brain Tumors |
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Authors: | Adnan El-Yazigi Ossama Al-Mefty |
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Affiliation: | Department of Cancer and Radiation Biology Research, Riyadh, Saudi Arabia;Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia |
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Abstract: | Abstract: CSF glutamine concentrations were studied in 12 patients with benign brain tumors (meningioma, craniopharyngioma, or osteofibroma), 12 patients with malignant brain tumors (astrocytoma, medulloblastoma, pinealoblastoma, or chondrosarcoma), 9 patients with non-cerebral tumors, and a reference group of 24 patients. The mean ± SD levels in the benign tumor group (424 ± 124 μ M ) were significantly lower (p < 0.0004) than those in the reference group (642 ± 195 μ M ). There was no significant difference between the CSF glutamine concentrations in the malignant cerebral tumor group (643 ± 210 μ M ) or noncerebral tumor group (599 ± 127 μ M ) and those in the reference group. In patients with benign brain tumors there was indication of an inverse linear relationship between the logarithm of CSF glutamine concentration and tumor diameter. |
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Keywords: | CSF glutamine Benign brain tumors Malignant brain tumors Correlation with tumor size |
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