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The comparison of susceptibility patterns of Gram-negative invasive and non-invasive pathogens in Estonian hospitals
Authors:Krista Lõivukene  Kadri Kermes  Epp Sepp  Vivika Adamson  Piret Mitt  Marika Jürna  Helle Mägi  Ülle Kallandi  Karin Otter  Paul Naaber
Institution:(1) Laboratory of Clinical Microbiology, United Laboratories of Tartu University Clinics, Puusepa 1A, 50406 Tartu, Estonia;(2) Department of Microbiology, University of Tartu, Ravila 19, 50406 Tartu, Estonia;(3) Infection Control Service, Tartu University Clinics, Puusepa 8, 50406 Tartu, Estonia;(4) North Estonian Regional Hospital, Sütiste 19, 13419 Tallinn, Estonia;(5) AstraZeneca, Järvevana tee 9, 11314 Tallinn, Estonia
Abstract:A total of 560 invasive and 1062 non-invasive isolates were collected. The antimicrobial susceptibility of invasive versus non-invasive Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae isolates were evaluated using the E-tests. The equal domination of Gram-negative among both invasive and non-invasive pathogens was estimated in our study if contaminants were excluded. The emergence trend of Gram-positive microbes especially of coagulase negative staphylococci may be proved only after application of exclusive algorithms. Due to similar susceptibility, the data of non-invasive Gram-negative pathogens can be useful to predict resistance of invasive ones. Also, the surveillance of invasive pathogens provides useful information about the general susceptibility of pathogens.
Keywords:Gram-negative invasive and non-invasive pathogens  Susceptibility
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