| Allopurinol can act as an electron transfer agent. Is this relevant during reperfusion injury? |
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| 收稿时间： | 1986-03-19 |
Allopurinol can act as an electron transfer agent. Is this relevant during reperfusion injury? |
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| D A Peterson,B Kelly,J M Gerrard. Allopurinol can act as an electron transfer agent. Is this relevant during reperfusion injury?[J]. Biochemical and biophysical research communications, 1986, 137(1): 76-79. DOI: 10.1016/0006-291X(86)91177-0 |
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| Authors: | D A Peterson B Kelly J M Gerrard |
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| Affiliation: | 1. Department of Orthopaedic Surgery, Xiangshan First People''s Hospital, Ningbo 315700, Zhejiang, China;2. Operating Room, Xiangshan First People''s Hospital, Ningbo 315700, Zhejiang, China;3. Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People''s Hospital, Shanghai 200233, China;1. Institute of Geological Sciences Polish Academy of Science, Research Centre in Kraków, Senacka 1, 31-002, Poland;2. Institute of Earth Sciences, Faculty of Natural Sciences, University of Silesia in Katowice, Będzińska 60, 41-200 Sosnowiec, Poland;3. Department of Geology, School of Natural Sciences, Trinity College Dublin, Ireland;4. Faculty of Geology and Geography, Sofia University "St. Kliment Ohridski", 15 Tzar Osvoboditel Blvd., 1504 Sofia, Bulgaria;5. Faculty of Geology, University of Warsaw, Żwirki i Wigury 93, 02-089 Warsaw, Poland |
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| Abstract: | The xanthine oxidase inhibitor allopurinol markedly enhances myocardial function and decreases ventricular irritability during myocardial reperfusion. In the present report, we have evaluated the molecular mechanism of allopurinol action. First, allopurinol was shown to be a weak radical scavenger. Second, allopurinol was found to act as an electron transfer agent from ferrous iron to ferric cytochrome c. The results suggest that the beneficial effect of allopurinol might partially result from its facilitated electron transport during reperfusion when the lipid components of the chain can be expected to be disordered. |
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