Monoclonal antibody to fibronectin which inhibits extracellular matrix assembly |
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| Authors: | M A Chernousov,A I Faerman,M G Frid,V E Printseva OYu Y" >Koteliansky |
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| Affiliation: | Institute of Experimental Cardiology, USSR Cardiology Research Center, Academy of Medical Sciences, 3rd Cherepkovskaya Str. 15 A, 121552 Moscow, USSR |
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| Abstract: | A monoclonal antibody L8 specific to fibronectin was shown to inhibit fibronectin incorporation into the fibroblast extracellular matrix. Antibody L8 could not interact with fibronectin complexed with gelatin. The results suggest the existence of a specific site on the fibronectin molecule playing a critical role in the assembly of the fibronectin extracellular matrix. This site is located near the collagen-binding domain. |
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