Regulation of the c-Abl and Bcr-Abl tyrosine kinases |
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| Authors: | Hantschel Oliver Superti-Furga Giulio |
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| Affiliation: | Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. hantschel@embl-heidelberg.de |
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| Abstract: | The prototypic non-receptor tyrosine kinase c-Abl is implicated in various cellular processes. Its oncogenic counterpart, the Bcr-Abl fusion protein, causes certain human leukaemias. Recent insights into the structure and regulation of the c-Abl and Bcr-Abl tyrosine kinases have changed the way we look at these enzymes. |
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