Lipid composition of cells and low-density lipoproteins in blood serum of human and some vertebrate species |
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Authors: | M V Lizenko T I Regerand A M Bakhirev E I Lizenko |
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Institution: | 1.Department of Facultative Therapy, Medical Faculty,Petrozavodsk State University,Petrozavodsk,Russia;2.Institute of Problems of Northern Waters, Karelian Research Center,Russian Academy of Sciences,Petrozavodsk,Russia;3.Institute of Biology, Karelian Research Center,Russian Academy of Sciences,Petrozavodsk,Russia |
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Abstract: | To establish interaction of atherogenic low-density lipoproteins (LDL) with the erythrocyte membrane, the content of lipid
components in blood cells and serum LDL was studied in healthy people (donors) and in 12 species of vertebrates (the mammals
non-predisposed to atherosclerosis — birds and fish). Lipid composition of blood cells and LDL was also analyzed in patients
with pathologies: ischemic heart disease (IHD), bronchial asthma (BA), and chronic obstructive bronchitis (COB), as well as
in 2 species of mammals predisposed to atherosclerosis, in whose blood LDL predominated. The content of lipids in the blood
cells and LDL of the studied vertebrates has been found to depend on their taxonomy and on the clear trends either for an
increase in the cholesterol content and a decrease in the phosphatidylcholine level in patients, particularly with IHD, or
for a rise of the ratio of the content of the more saturated sphingomyelin and cholesterol to the less saturated phosphatidylcholine
from the lower to the higher organisms, including humans (donors). The highest levels of free cholesterol in blood cells of
total cholesterol in LDL, as well as of parameters of ratio of the cholesterol/phosphatidylcholine content have been revealed
in patients, especially with IHD, and in the mammals predisposed to atherosclerosis, i.e. in representatives with predominance
of blood LDL, in contrast to donors and the mammals resistant to atherosclerosis. The highest parameters of lipid components
were determined in blood cells and LDL in patients with IHD. The lipid LDL composition affects directly the composition and
ratio of lipids in blood cells. |
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