|
|||||
|
|
Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase |
|
| Authors: | V. V. Burmistrov G. M. Butov D. S. Karlov V. A. Palyulin N. S. Zefirov C. Morisseau B. D. Hammock |
| Affiliation: | 1.Volzhskii Polytechnical Institute (Branch),Volgograd State Technical University,Volzhskii,Russia;2.Department of Chemistry,Moscow State University,Moscow,Russia;3.Department of Entomology and Nematology and UC Davis Comprehensive Cancer Center,University of California,Davis,USA;4.ISCALARE Laboratory,Moscow Institute of Physics and Technology (State University),Dolgoprudnyi, Moscow oblast,Russia |
| Abstract: | A series of target-oriented competitive inhibitors of human soluble epoxide hydrolase have been synthesized. The compounds retain the inhibitory properties at concentrations down to 4 nM. Based on the results of molecular modeling, it has been shown that the high inhibitory activity of this series of compounds is achieved by a unique mode of the binding to the active site of the enzyme. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |