DNA sequence-specific ligands: XV. Synthesis and spectral characteristics of a new series of dimeric bisbenzimidazoles DB(1, 2, 6, 8, 9, 10, 12) |
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| Authors: | A. A. Ivanov V. I. Salyanov A. L. Zhuze |
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| Affiliation: | 1.Engelhardt Institute of Molecular Biology,Russian Academy of Sciences,Moscow,Russia;2.Research Institute of Carcinogenesis, Blokhin Russian Oncological Research Center,Russian Academy of Medical Sciences,Moscow,Russia |
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| Abstract: | Seven fluorescent symmetric dimeric bisbenzimidazoles DB(n) capable of occupying up to one turn of the double-stranded B-form DNA have been designed and synthesized with the aim to develop DNAdependent enzyme inhibitors. The DB(n) compounds contain four 2,6-substituted benzimidazole fragments and differ by the length of the oligomethylene linker (n = 1, 2, 6, 8, 9, 10, 12) between the bisbenzimidazole blocks. The formation of DB(n)–double-stranded DNA complexes and the localization of the ligands in the DNA minor groove have been confirmed by a number of physicochemical methods. |
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