| PAD4:一种治疗类风湿性关节炎的新靶酶 |
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| 引用本文： | 周剑涛,丁海峰. PAD4:一种治疗类风湿性关节炎的新靶酶[J]. 生命的化学, 2008, 28(6) |
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| 作者姓名： | 周剑涛 丁海峰 |
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| 作者单位： | 黄冈卫生学校,黄州,438000;黄冈卫生学校,黄州,438000 |
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| 摘 要： | 肽酰基精氨酸脱亚氨酶4(PAD4)催化肽酰精氨酸残基转变为肽酰瓜氨酸残基,其活性失调与类风湿性关节炎(RA)的发生与发展有关.目前PAD4被认为是开发新RA治疗药物的一种新靶酶.认识PAD4的结构与可能的作用机制,对于开发新RA治疗药物是重要的.
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| 关 键 词： | 肽酰基精氨酸脱亚氨酶4 类风湿性关节炎 PAD4抑制剂 |
PAD4:a novel therapeutic target for rheumatoid arthritis |
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| Jian-Tao ZHOU,Hai-Feng DING. PAD4:a novel therapeutic target for rheumatoid arthritis[J]. Chemistry of Life, 2008, 28(6) |
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| Authors: | Jian-Tao ZHOU Hai-Feng DING |
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| Affiliation: | Jian-Tao ZHOU Hai-Feng DING (Huanggang Health School,Huangzhou 438000,China) |
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| Abstract: | Peptidylarginine deiminase 4 (PAD4) catalyzes the conversion of peptidyl-arginine to peptidyl-citrulline. The dysfunction of PAD4 is generally considered to play a causative role in rheumatoid arthritis (RA) disease onset and progression. This enzyme has recently emerged as a new target for the development of a novel RA therapeutic medicament. It is important to understand the structure and possible mechanism of PAD4 for developing PAD4-inhibiting drugs. |
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| Keywords: | peptidylarginine deiminase 4 rheumatoid arthritis PAD4 inhibitor |
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