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PAD4:一种治疗类风湿性关节炎的新靶酶
引用本文:周剑涛,丁海峰.PAD4:一种治疗类风湿性关节炎的新靶酶[J].生命的化学,2008,28(6).
作者姓名:周剑涛  丁海峰
作者单位:黄冈卫生学校,黄州,438000
摘    要:肽酰基精氨酸脱亚氨酶4(PAD4)催化肽酰精氨酸残基转变为肽酰瓜氨酸残基,其活性失调与类风湿性关节炎(RA)的发生与发展有关.目前PAD4被认为是开发新RA治疗药物的一种新靶酶.认识PAD4的结构与可能的作用机制,对于开发新RA治疗药物是重要的.

关 键 词:肽酰基精氨酸脱亚氨酶4  类风湿性关节炎  PAD4抑制剂

PAD4:a novel therapeutic target for rheumatoid arthritis
Jian-Tao ZHOU,Hai-Feng DING.PAD4:a novel therapeutic target for rheumatoid arthritis[J].Chemistry of Life,2008,28(6).
Authors:Jian-Tao ZHOU  Hai-Feng DING
Institution:Jian-Tao ZHOU Hai-Feng DING (Huanggang Health School,Huangzhou 438000,China)
Abstract:Peptidylarginine deiminase 4 (PAD4) catalyzes the conversion of peptidyl-arginine to peptidyl-citrulline. The dysfunction of PAD4 is generally considered to play a causative role in rheumatoid arthritis (RA) disease onset and progression. This enzyme has recently emerged as a new target for the development of a novel RA therapeutic medicament. It is important to understand the structure and possible mechanism of PAD4 for developing PAD4-inhibiting drugs.
Keywords:peptidylarginine deiminase 4  rheumatoid arthritis  PAD4 inhibitor  
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