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An image analysis toolbox for high-throughput C. elegans assays |
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| Authors: | Wählby Carolina Kamentsky Lee Liu Zihan H Riklin-Raviv Tammy Conery Annie L O'Rourke Eyleen J Sokolnicki Katherine L Visvikis Orane Ljosa Vebjorn Irazoqui Javier E Golland Polina Ruvkun Gary Ausubel Frederick M Carpenter Anne E |
| Institution: | Imaging Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA. carolina@broadinstitute.org |
| Abstract: | We present a toolbox for high-throughput screening of image-based Caenorhabditis elegans phenotypes. The image analysis algorithms measure morphological phenotypes in individual worms and are effective for a variety of assays and imaging systems. This WormToolbox is available through the open-source CellProfiler project and enables objective scoring of whole-worm high-throughput image-based assays of C. elegans for the study of diverse biological pathways that are relevant to human disease. |
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