| 木脂素类化合物的SOD活性研究 |
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| 引用本文： | 鲁纯素 史禄文. 木脂素类化合物的SOD活性研究[J]. 天然产物研究与开发, 1989, 1(1): 78-81 |
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| 作者姓名： | 鲁纯素 史禄文 |
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| 作者单位： | 北京医科大学药学院，北京医科大学药学院，北京医科大学药学院，北京医科大学药学院 |
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| 基金项目： | 国家自然科学基金资助的课题 |
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| 摘 要： | 超氧化物歧化酶,是生物体内对超氧阴离子自由基(O_2~-)的最有效的清除剂,但由于SOD分子量大,体内代谢速度快,作为外源性药物有其不足之处。从中草药中寻找具SOD活性的有效成分,更好发掘天然药物的研究。从地血香分离出四种联苯环烯木脂素类化合物,进行了SOD活性研究。实验证明四种化合物的SOD活性不同,分别测定了它们对O_2~-的清除率和抑制率。
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| 关 键 词： | 木脂素类 超氧负离子自由基 超氧化物歧化酶 |
STUDY ON THE SOD ACTIVITY OF LIGNANS |
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| LU Chun-su,et al. STUDY ON THE SOD ACTIVITY OF LIGNANS[J]. Natural Product Research and Development, 1989, 1(1): 78-81 |
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| Authors: | LU Chun-su et al |
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| Abstract: | The SOD activities of Lignans have been investigated by inderict method i, e, O_2~(?) is generated by KO_2-NBT in DMSO systems. These compounds, four minor components as Gominsin A, Gominsin B, Schizandrin and Angeloxylgominsin H were isolated from Di Xue Xiang, one of the traditional Chinese drug, its might act as a scavenger of O_2~(?). The scavenging ratio and inhibition ratio of these compounds were measured. The SOD activity of Schizamddin is stronger than others. |
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| Keywords: | Lignans Superoxide radical Superoxide dismutase |
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