Effects of dietary phosphorus intake on bone mineralization and calcium absorption in adult female rats |
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Authors: | Koshihara Moyuru Katsumata Shin-Ichi Uehara Mariko Suzuki Kazuharu |
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Affiliation: | Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture. |
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Abstract: | We investigated the effects of dietary phosphorus (P) intake on the bone mineralization and calcium (Ca) absorption in adult female rats. Fifteen 16-wk-old female Wistar rats were divided into three groups, and respectively fed a low-P diet containing 0.15% P (LP), a control diet containing 0.5% P (C), and a high-P diet containing 1.5% P (HP) for 42 d. The apparent Ca absorption was significantly increased with decreasing dietary P level. The serum parathyroid hormone concentration was significantly lower in the LP group than in the C and HP groups. The serum osteocalcin concentration and urinary excretion of deoxypyridinoline were significantly higher in the HP groups than in the LP and C groups. The bone mineral density of the fifth lumbar vertebra was significantly increased with decreasing dietary P level. These results indicate that the low-P diet increased Ca absorption, this being effective for bone mineralization in adult female rats. |
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