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Enantiomeric resolution by HPLC of axial chiral amides using amylose tris[(S)-1-phenylethylcarbamate]
Authors:Quezia B Cass  Ana Luiza G Degani  M Elizabeth Tiritan  Stephen A Matlin  Dennis P Curran  Aaron Balog
Abstract:The enantiomeric resolution of a series of N-arylamides was examined on amylose tris(S)-1-phenylethylcarbamate] coated onto aminopropylated 7 μm silica with 500 Å diameter pores and on naked silica 5 μm particle size with 500 Å diameter pores. The enantiomeric resolution obtained for this series was excellent on both columns. The enantioselectivity of cellulose and amylose tris (3,5-dimethylphenylcarbamate) coated onto APS-Hypersil (120 Å pore size, 5 μm particle size) was also investigated for this series of compounds. Chirality 9:109–112, 1997. © 1997 Wiley-Liss, Inc.
Keywords:N-arylamides  carbohydrate carbamate  axial chirality
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