Proconflict effect of carbon dioxide inhalation in rats |
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| Affiliation: | 1. Neurobiology Unit, Department of Cell Biology, Interdisciplinary Research Structure for Biotechnology and Biomedicine (BIOTECMED), Universitat de Valencia, Spain;2. Neuroscience Center, University of Helsinki, Finland;3. CIBERSAM: Spanish National Network for Research in Mental Health, Spain;4. Fundación Investigación Hospital Clínico de Valencia, INCLIVA, Valencia, Spain;1. Service d’endocrinologie diabétologie nutrition, CHU Grenoble-Alpes, CS 10217, boulevard de la Chantourne, 38043 Grenoble cedex 9, France;2. Service de médecine interne, endocrinologie et nutrition, hôpitaux universitaires de Strasbourg, 67098 Strasbourg cedex, France;3. Service des maladies endocriniennes et métaboliques, hôpital Cochin, CHU Paris Centre, 75014 Paris, France;1. Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany;2. Institute for Stroke and Dementia Research, University Hospital Munich, Max-Lebsche-Platz 30, 81377 Munich, Germany;3. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany;4. Department of Internal Medicine and Laboratory Medicine, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany;5. Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary;6. Division of Brain Sciences, Imperial College, London, UK;1. Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center Rotterdam/Sophia Children''s Hospital, Rotterdam, The Netherlands;2. Department of Child Development, Faculty of Psychology and Education, Vrije Universiteit, Amsterdam, The Netherlands;3. Department of Psychiatry, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands;4. Faculty of Social and Behavioral Science, University of Amsterdam, Amsterdam, The Netherlands |
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| Abstract: | The effect of brief inhalation of carbon dioxide (CO2) was studied in a conflict situation (Vogel test) in the rat. This treatment, which inhibits γ-aminobutyric acid (GABA)-mediated transmission in rat brain and induces anxiety and panic attacks in humans, elicited a proconflict effect. Exposure of rats for l min to CO2 decreased by ~ 40% the number of licking periods in the test. This effect was abolished by prior administration of alprazolam (0.5 mg per kilogram of body Mass, I.p.). Although these results may support a role for GABA-mediated transmission in the anxiogenic effect of CO2 inhalation, the possibility that different neurotransmitters other than GABA are involved in the action of CO2 can not be ruled out. |
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