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On the odor of the enantiomers of Madrol® |
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| Authors: | Gerhard Buchbauer Philippine Lebada Lucia Wiesinger Petra Weiss-Greiler Peter Wolschann |
| Abstract: | The asymmetric syntheses of the enantiomers of Madrol® ( 1 ) are described and their odor properties evaluated. (1S)-(−)- 1 exerts a powerful sandalwood odor with some animalic undertones, whereas its antipode smells sweet and flowery rather than like sandalwood. Molecular surface comparisons show remarkable deviations in the hydrophobic parts of the two enantiomers. Chirality 9:380–385, 1997. © 1997 Wiley-Liss, Inc. |
| Keywords: | asymmetric synthesis campholene aldehyde derivatives fragrance compounds sandalwood odor santalum album L structure-odor-relationships molecular similarity molecular modeling computer-aided fragrance design molecular surface comparison |