| 蛹虫草缓解新型冠状病毒感染研究进展 |
| |
| 引用本文： | 怀美玉,徐方旭,刘梦潜,董彩虹. 蛹虫草缓解新型冠状病毒感染研究进展[J]. 微生物学杂志, 2024, 0(2): 109-119 |
| |
| 作者姓名： | 怀美玉 徐方旭 刘梦潜 董彩虹 |
| |
| 作者单位： | 沈阳师范大学 生命科学学院，辽宁 沈阳 110034;2.辽宁省功能性蛹虫草重点实验室，辽宁 沈阳 110034；3.沈阳师范大学 实验教学中心，辽宁 沈阳 110034；4.沈阳市功能性蛹虫草产业技术研究院，辽宁 沈阳 110034;中国科学院 微生物研究所，北京 100101;2.辽宁省功能性蛹虫草重点实验室，辽宁 沈阳 110034；5.中国科学院 微生物研究所，北京 100101 |
| |
| 基金项目： | 辽宁省科技厅面上项目（2023-MS-251）；辽宁省教育厅重点攻关项目（LJKZZ20220116） |
| |
| 摘 要： | 严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的COVID-19在全球范围内大流行，危害了人类健康和公共安全，随着对SARS-CoV-2的结构、功能和致病过程的了解，越来越多的潜在药物被开发。蛹虫草(Cordyceps militaris)是我国传统的药用真菌，具有显著的抗病毒作用，虫草素作为蛹虫草的主要活性成分能够与SARS-CoV-2刺突蛋白、主蛋白酶(Mpro)相结合，抑制病毒RNA依赖的RNA聚合酶(RDRP)活性，阻断SARS-CoV-2在机体内复制。蛹虫草还具有提升机体免疫力、修复受损组织的作用。本文概述虫草素抗SARS-CoV-2的机制和蛹虫草其他相关药理作用，以期为蛹虫草用于新型冠状病毒感染的辅助治疗提供参考。
|
| 关 键 词： | 蛹虫草 SARS-CoV-2 新型冠状病毒感染 虫草素 免疫调节 |
Advances in Alleviating Novel Coronavirus Infection with Cordyceps militaris |
| |
| HUAI Mei-yu,XU Fang-xu,LIU Meng-qian,DONG Cai-hong. Advances in Alleviating Novel Coronavirus Infection with Cordyceps militaris[J]. Journal of Microbiology, 2024, 0(2): 109-119 |
| |
| Authors: | HUAI Mei-yu XU Fang-xu LIU Meng-qian DONG Cai-hong |
| |
| Affiliation: | College of Life Science,Shenyang 110034;2. Liaoning Key Lab. of Cordyceps militaris with Functional Val.,Shenyang 110034; 3. Exp. Teach. Ctr., Shenyang Normal Uni.,Shenyang 110034; 4. Shenyang Functional Cordyceps militaris Indust. Technol. Res. Inst.，Shenyang 110034;Inst. of Microbiol., Chinese Acad. of Sci., Beijing 100101; 2. Liaoning Key Lab. of Cordyceps militaris with Functional Val.,Shenyang 110034;5. Inst. of Microbiol., Chinese Acad. of Sci., Beijing 100101 |
| |
| Abstract: | COVID-19 caused by SARS-CoV-2 is a global pandemic disease, endangering human health and public safety. With the understanding of the structure, function and pathogenic process of SARS-CoV-2, more and more potential drugs are being developed.Cordyceps militaris is a traditional medicinal fungus that has significant antiviral effects. Cordycepin is the main active component of C.militaris which can combine with SARS-CoV-2 spike protein and main protease (Mpro), inhibit viral RdRp polymerase, and prevent SARS-CoV-2 from replicating in the body. C.militaris also has the function of improving the body′s immunity and repairing damaged tissues. The anti-SARS-CoV-2 mechanism of cordycepin and other related pharmacological functions of C. militaris were summarized. This review will provide reference for the adjuvant therapy of cordycepin for COVID-19. |
| |
| Keywords: | Cordyceps militaris SARS-CoV-2 COVID-19 cordycepin immunoregulation |
|
| 点击此处可从《微生物学杂志》浏览原始摘要信息 |
|
点击此处可从《微生物学杂志》下载全文 |
