Zymosan-induced arthritis in rats II. Effects of anti-inflammatory drugs |
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| Institution: | 1. Superior Institute of Biomedical Sciences, State University of Ceara, Av. Dr. Silas Munguba, 1700, Itaperi, 60714-903, Fortaleza, CE, Brazil;2. Department of Oral Pathology and Clinical Stomatology of Federal University of Ceara, Rua Coronel Nunes Valente, 1127, Rodolfo Teófilo, 607430-970, Fortaleza, CE, Brazil;3. Departament of Physiology and Pharmacology, Federal University of Ceara, Rua Coronel Nunes Valente, 1127, Rodolfo Teófilo, 607430-970, Fortaleza, CE, Brazil;4. Department of Organic and Inorganic Chemistry, Federal University of Ceara, Rua Humberto Monte, S/N, Campus de PICI, 60440554, Fortaleza, CE, Brazil;5. Faculty of Education Science and Letters of the Hinterland, Rua José de Queiroz Pessoa, 2554 – Planalto Universitário, 63.900-000, Quixadá, CE, Brazil;1. CHU de Bordeaux, 33076 Bordeaux, France;2. CEIP-Addictovigilance Marseille, 13385 Marseille, France;3. CEIP-Addictovigilance Grenoble, 38043 Grenoble, France;4. CEIP-Addictovigilance Toulouse, 31000 Toulouse, France;5. CEIP-Addictovigilance Nantes, 44093 Nantes, France;6. CEIP-Addictovigilance Montpellier, 34295 Montpellier, France;7. CEIP-Addictovigilance Caen, 14033 Caen, France;8. CEIP-Addictovigilance Lille, 59037 Lille, France;9. CEIP-Addictovigilance Lyon, 69460 Lyon, France;10. CEIP-Addictovigilance Poitiers, 86021 Poitiers, France;11. CEIP-Addictovigilance Clermont-Ferrand, 63003 Clermont-Ferrand, France;12. CEIP-Addictovigilance Paris, 75475 Paris, France;13. CEIP-Addictovigilance Nancy, 54511 Nancy, France;14. CEIP-Addictovigilance de Bordeaux, CHU de Bordeaux, Bordeaux, France;1. Unigen Inc., 3005 1st Ave., Seattle, WA 98121, USA;2. Unigen Inc., #450-86, Maebong-Ro, Dongnam-Gu, Cheonan-Si, Chungnam 330-863, Republic of Korea;1. Livestock and Wildlife Laboratory, Arid Lands Institute, Route Djorf Km 22, 4119 Medenine, Tunisia;2. Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences, Tunis-El Manar University, Tunisia;3. Office de l’Elevage et des Pâturages, 30 rue Alain Savary, 1002 Tunis, Tunisia;4. CITA, 50059 Zaragoza, Spain;5. ARAID, 50004 Zaragoza, Spain;1. LEFFAG - Laboratório de Estudos da Fisio-Farmacologia Gastrintestinal, Centro de Biomedicina, Rua Coronel Nunes de Melo, 1315, 60430-270 Fortaleza, CE, Brazil;2. Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, 60740-000 Fortaleza CE, Brazil;3. Faculdade de Educação, Ciências e Letras do Sertão Central, Universidade Estadual do Ceará, Rua José de Queirós Pessoa, 2554, 63900-000 Quixadá, Ceará, Brazil;4. Departamento de Morfologia, Universidade Federal do Ceará, Rua Delmiro de Farias s/n, 60430-170, Fortaleza, CE, Brazil |
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| Abstract: | As zymosan-induced arthritis in rats combines dual activation of early prostaglandindependent processes (edema, fever, pain) and IL-1 related effects on cartilage metabolism, we compared the respective influences of indomethacin (IMT) and dexamethasone (DEX) on its course. Different parameters were assessed: knee swelling, febrile response, loss of activity, cartilage metabolism and histology. DEX improved all these parameters, while IMT exerted only light beneficial effects on fever and knee swelling without obvious beneficial influence on cartilage metabolism and histological lesions. These results suggest that anti-inflammatory activities of DEX and IMT are due to interferences with different pathways during zymosan-induced arthritis in rats. |
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