Chromosomal localization of opioid peptide and receptor genes in the mouse |
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| Affiliation: | 1. INSERM U-288, Neurobiologie Cellulaire et Fonctionnelle,CHU Pitié-Salpêtrière, 91 Boulevard de l''Hôpital, 75634 Paris Cedex 13, France;1. Dept. of Medicine, Div. of Rheumatology and Immunology, Lab. of Molecular Genetics, Duke University Medical Center, Durham, NC 27710, USA;1. NeuroCenter, Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109A, CH-3012, Bern, Switzerland;2. Graduate School for Cellular and Biomedical Sciences, University of Bern, Freiestrasse 1, CH-3012, Bern, Switzerland;1. Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Republic of Korea;2. College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Republic of Korea;3. Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chung-Ju 380-701, Republic of Korea;4. Department of Immunology, Konkuk University, Chung-Ju 380-701, Republic of Korea;5. Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Republic of Korea;6. Department of Medicine, Pusan Paik Hospital, Collage of Medicine, Inje University, Busan 633-165, Republic of Korea;1. Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China;2. State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi''an 710032, China;1. Unit of Biophysics Dept of Biochemistry and Molecular Biology, Institute of Neurosciences, Universitat Autònoma de Barcelona, Facultat de Medicina, 08193 Cerdanyola del Vallés, Catalonia, Spain;2. Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden;3. Laboratory of Molecular Biophysics, Department of Physics, University Jaume I, 12071 Castellón, Spain;4. Unitat de Síntesis i Aplicacions Biomèdiques de Pèptids, Institut de Química Avançada de Catalunya, IQAC-CSIC, Jordi Girona, 18-26, 08034 Barcelona, Catalonia, Spain;5. Laboratory of Molecular Physiology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain |
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| Abstract: | Opiate receptors are the primary targets for the drugs of abuse morphine and heroin. In this study, we completed the localization on mouse chromosomes of the genes encoding mu (Oprm) and kappa (Oprk) receptors, as well as the genes for the opioid propeptides proenkephalin (Penk) and prodynorphin (Pdyn). The genetic mapping was performed using a panel of DNA samples from an interspecific cross [C3H/HeJ-gld and (C3H/HeJ-gld x Mus spretus)Fi] that has been characterized for more than 800 markers throughout the genome. The genes are localized on mouse Chr 1 (Oprk, 10 cM from the centromere), Chr 2 (Pdyn, 75 cM from the centromere), Chr 4 (Penk, 1 cM from the centromere) and Chr 10 (Oprm, 10 cM from the centromere). Interestingly, the gene for the mu receptor is located in the same region as a Quantitative Trait Locus for high morphine consumption, thus raising the possibility of its direct role in drug abuse mechanisms. |
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