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Depolarization of the cell membrane causes inhibition of cell locomotion and pinocytosis inAcanthamoeba castellanii andAmoeba proteus
Authors:K. Dolowy
Affiliation:(1) Department of Biophysics and Biomathematics, Medical Center of Postgraduate Education, Warszawa
Abstract:Summary 10 mgrM CCCP protonophore in an acidic medium causes depolarization of the cell membrane and immediate cessation of locomotion inAcanthamoeba castellanii andAmoeba proteus. In the basic media there is no depolarization or inhibition of cell locomotion. Other depolarizing agents (alkali cations, crown molecules) also stop locomotion and induce pinocytosis in amoeba. Pinocytotic uptake of horseradish peroxidase byAcanthamoeba castellanii is increased by 69% in the presence of CCCP in the medium at pH 5.7 but is not influenced at higher pH values. This might indicate that both amoeboid locomotion and pinocytosis are controlled by membrane potential.
Keywords:Acanthamoeba  Amoeba proteus  Amoeboid locomotion  15-crown-5  Kryptofix 222  Nigericin  Membrane potential  Pinocytosis  Protonophores  Valinomycin
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