Substance P scavenger enhances antioxidant defenses and prevents prothrombotic effects on the rat lung after acute exposure to oil smoke |
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| Authors: | Li Ping-Chia Lai I-Ju Lin Yu-Ching Chang Li-Ching Chen Wen-Chung |
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| Affiliation: | (1) Department of Occupational Therapy, I-Shou University, Jiau-Shu Tsuen, Yan-Chau Shiang, Kaohsiung County, No. 8 E-Da Road, 824 Taiwan, R.O.C;(2) Department of Medical Nutrition, I-Shou University, Jiau-Shu Tsuen, Yan-Chau Shiang, Kaohsiung County, No. 8 E-Da Road, 824 Taiwan, R.O.C;(3) Department of Physical Medicine and Rehabilitation, E-DA Hospital, Jiau-Shu Tsuen, Yan-Chau Shiang, Kaohsiung County, No. 1 E-Da Road, 824 Taiwan, R.O.C;(4) Department of Pathology, National Cheng Kung Univeristy Hospital, No. 138 ShengLi Rd., Tainan City, Taiwan, R.O.C |
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| Abstract: | Background Airborne particulate matter, from cooking oil, smoking, engine exhaust and other sources, is associated with the development of atherosclerosis and myocardial infarction. In order to explore the cellular and molecular events following exposure of rats to lard oil smoke, we measured the generation of reactive oxygen species (ROS), substance P, cellular adhesion molecules, and thrombosis in relation to inhibitors of substance P, the NK-1 receptor, and antioxidants. |
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