Role of the H1 haplotype of microtubule-associated protein tau (MAPT) gene in Greek patients with Parkinson's disease |
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Authors: | Nikolaos Refenes Juliane Bolbrinker Georgios Tagaris Antonio Orlacchio Nikolaos Drakoulis and Reinhold Kreutz |
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Institution: | (1) School of Pharmacy, Department of Pharmaceutical Technology, National and Kapodistrian University of Athens, Athens, Greece;(2) Institute of Clinical Pharmacology and Toxicology, Charit? – Universit?tsmedizin Berlin, Berlin, Germany;(3) Department of Neurology, "G. Gennimatas" General Hospital, Athens, Greece;(4) Laboratory of Neurogenetics, CERC-IRCCS Santa Lucia, Rome, Italy;(5) Department of Neuroscience, University of Rome "Tor Vergata", Rome, Italy |
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Abstract: | Background The extended tau haplotype (H1) that covers the entire human microtubule-associated protein tau (MAPT) gene has been implicated in Parkinson's disease (PD). Nevertheless, controversial results, such as two studies in Greek
populations with opposite effects, have been reported. Therefore, we set out to determine whether the H1 haplotype and additional
single nucleotide polymorphisms (SNPs) included in H1 are associated with PD in a sample of Greek patients. |
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