Polymorphisms of interleukin-4, -10 and 12B genes and diabetic retinopathy |
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Authors: | Ines Cilen?ek Amela Hercegovac Jovana Nikolajevi? Star?evi? Katarina Vukojevi? Mirna Saraga Babi? Aleksandra Milutinovi? ?ivin |
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Institution: | (1) Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Aravind Eye Hospital, #1, Anna Nagar, Madurai, 625 020, India;(2) Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, Bethesda, MD, USA;(3) Retina Clinic, Aravind Eye Hospital, #1, Anna Nagar, Madurai, 625 020, India;(4) Ophthalmic Genetics and Visual Function Branch, National Eye Institute, NIH, 5635 Fisher's Lane, Rockville, MD 20852, USA |
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Abstract: | In diabetic retinopathy (DR) and other angiogenesis-associated diseases, increased levels of cytokines, inflammatory cells,
and angiogenic factors are present. We investigated the hypothesis that rs2243250 polymorphism of the interleukin 4 (IL-4) gene or rs1800896 polymorphism of the interleukin 10 (IL-10) gene, and rs3212227 polymorphism of the 3’ untranslated region (3’ UTR) of the interleukin-12 p40 gene (IL12B) may be associated with the development of proliferative diabetic retinopathy (PDR) in Caucasians with type 2 diabetes (DM2).
This cross sectional case — control study included 189 patients with PDR and 187 patients with type 2 diabetes without PDR.
Polymorphisms rs1800896 of the IL-10 gene, rs2243250 of the IL-4 gene, and rs3212227 of IL12B gene were analyzed by ARMS -PCR and RFLP -PCR methods. Multivariate analysis demonstrated the GG genotype of the rs1800896
polymorphism of the IL-10 gene to be associated with increased risk for PDR (OR=1.99; 95% CI=1.11–3.57; P=0.02), whereas the TT genotype of the rs2243250
polymorphism of the IL-4 gene and the AA genotype of the rs3212227 polymorphism of the IL-12 gene were not independent risk factors for PDR. Our findings suggest that the genetic variations at the IL-10 promoter gene might be a genetic risk factor for PDR in Caucasians with type 2 diabetes. |
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