Combined effect of betaine and trehalose on osmotic tolerance of <Emphasis Type="Italic">Escherichia coli</Emphasis> in mineral salts medium |
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Authors: | E N Miller L O Ingram |
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Institution: | (1) Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611, USA |
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Abstract: | In mineral salts medium, supplementing with betaine in combination with increased production of endogenous osmoprotectant
from a second copy of the trehalose biosynthetic genes (otsBA) improved growth of E. coli and increased the MIC for xylose, glucose, sodium lactate and NaCl. With these compounds, this combination was more effective
than either betaine or trehalose alone. With succinate, this combination was no more effective than betaine alone. Neither
approach improved tolerance to ethanol. A combination of betaine and increased trehalose may improve strain productivity for
many bioproducts by promoting growth in the presence of high sugar concentrations. |
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Keywords: | Betaine E coli Lactate Osmotic stress Trehalose |
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