| Abstract: | Equine haptoglobin (Hp) and haptoglobin-haemoglobin complex (Hp-Hb) are metabolised in the hen parenchymal cells of the liver in which endocytosis was inhibited by agalacto-orosomucoid (AGOR) or native orosomucoid (OR). The intravenous administration of AGOR or OR together with 125I]Hp slightly decreased clearance of Hp from circulation. This suggested that heterologous Hp could be catabolised by the alternative pathway following the uptake by the liver RES cells. Administration of the 125I]Hp-Hb complex and AGOR was of no effect on the clearance of the Hp-Hb complex. |
