| 小鼠Sry基因和Sox基因的克隆分离与鉴定 |
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| 引用本文： | 张晓群,王申五,陈东,陈永福,陆道培.小鼠Sry基因和Sox基因的克隆分离与鉴定[J].中国生物化学与分子生物学报,1997,13(4):391-395. |
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| 作者姓名： | 张晓群 王申五 陈东 陈永福 陆道培 |
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| 作者单位： | 北京医科大学人民医院血液研究所 |
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| 摘 要： | 为了深入探讨性分化分子机制，构建了小鼠基因文库以ＳＲＹ探针筛选，分离到了两组阳性克隆，一组含ＥｃｏＲⅠ／３．５ｋｂ，此片段中载有小鼠Ｙ染色体上的Ｓｒｙ基因．另一组含ＥｃｏＲⅠ／３．０ｋｂ或ＳａｌⅠ／３．０ｋｂ，此片段有小鼠Ｙ染色体之外的Ｓｏｘ基因
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| 关 键 词： | 小鼠基因文库 小鼠Y性别决定区 小鼠性别决定相关基因 |
| 收稿时间： | 1997-08-20 |
Isolation and Analysis of the Mouse Sry and Sox Genes |
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| Zhang Xiao,Qun,Wang Shen,Wu,Chen Dong,,Chen Yong,Fu,,Lu Dao,Pei.Isolation and Analysis of the Mouse Sry and Sox Genes[J].Chinese Journal of Biochemistry and Molecular Biology,1997,13(4):391-395. |
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| Authors: | Zhang Xiao Qun Wang Shen Wu Chen Dong Chen Yong Fu Lu Dao Pei |
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| Institution: | (Institute of Hematology, People′s Hospital,Beijing Medical University,Beijing 100044) (National Agrobiotechnology Laboratory, Beijing Agricultural University |
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| Abstract: | An EcoRⅠor SalⅠ3.0 kb fragment and EcoRⅠ3.5 kb fragment from the positive clones screened by SRY probe in male mouse genomic library and forced cloning library were described respectively.The 3.0 kb fragment containing SRY box is located outside of Y chromosome mamely the Sox gene and the Sry gene of Kun Ming white mice is included in the 3.5kb fragment. |
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| Keywords: | Mouse genomic library Sry gene Sox gene |
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