|
|||||
|
|
Microtubule cytoskeleton behavior in the initial steps of host cell invasion by Besnoitia besnoiti |
|
| Authors: | Reis Y Cortes H Viseu Melo L Fazendeiro I Leitão A Soares H |
| Affiliation: | a Instituto de Investigação Científica Tropical, CVZ, CIISA, Av. Universidade Técnica, Lisboa 1300-477, Portugal b Laboratório de Parasitologia, Núcleo da Mitra, Universidade de Évora (ICAM), Ap. 947002-554, Portugal c Departamento de Física, Instituto Superior Técnico, Lisboa 1049-001, Portugal d Faculdade de Medicina Veterinária CIISA, Av. Universidade Técnica, Lisboa 1300-554, Portugal e Instituto Gulbenkian de Ciência, Apartado 14, 2781-901 Oeiras, Portugal f Escola Superior de Tecnologia da Saúde de Lisboa, 1990-096 Lisboa, Portugal |
| Abstract: | Besnoitia besnoiti is a protozoan parasite responsible for bovine besnoitiosis. Indirect immunofluorescence showed that isolated B. besnoiti possesses a set of subpellicular microtubules, radiating from the apical end and extending for more than 2/3 of the cell body. Upon interaction with the host cell, B. besnoiti undergoes dramatic modifications of shape and surface, as revealed by atomic force microscopy, accompanied by a distinct tubulin labeling on the posterior region. In the host cell, the microtubule cytoskeleton shows a re-arrangement around the invading parasite suggesting a filamentous interaction with the parasite cytoskeleton during invasion. |
| Keywords: | Cytoskeleton Microtubules Host cell invasion Besnoitia besnoiti |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |