Links between replication, recombination and genome instability in eukaryotes |
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| Authors: | Flores-Rozas H Kolodner R D |
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| Affiliation: | Ludwig Institute for Cancer Research, Cancer Center and Dept of Medicine, University of California-San Diego School of Medicine, La Jolla, CA 92093, USA. |
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| Abstract: | Double-strand breaks in DNA can be repaired by homologous recombination including break-induced replication. In this reaction, the end of a broken DNA invades an intact chromosome and primes DNA replication resulting in the synthesis of an intact chromosome. Break-induced replication has also been suggested to cause different types of genome rearrangements. |
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