A general interactive model for B cell activation |
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Authors: | Allen J. Rosenspire Diane M. Jacobs |
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Affiliation: | 1. Department of Biophysical Sciences and Microbiology, State University of New York at Buffalo, 14214, Buffalo, NY
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Abstract: | The general interactive model described in the previous paper was subjected to experimental testing. We examined the high affinity anti-TNP? plaqueforming cell response of cultures of murine lymphocytes exposed to lipopolysaccharide and trinitrophenylated lipopolysaccharide (TNP-LPS). From our model we predicted the effects of the addition of free LPS on the dose response to TNP-LPS, the effect of the addition of Polymyxin B to cultures stimulated with TNP-LPS, and the effect on the response to TNP-LPS preparations with different haptenation ratios. The results obtained were consistent with the predictions of the general interactive model. |
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