Computer modeling studies of the structure of a repressor |
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Authors: | W F Anderson M Cygler |
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Affiliation: | 2. MRC Group on Protein Structure and Function, Department of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7 Canada;1. Department of Crystallography, University of Lód?, 91-416 Lód?, Nowotki 18 Poland |
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Abstract: | Due to advances in molecular biology the DNA sequences of structural genes coding for proteins are often known before a protein is characterized or even isolated. The function of a protein whose amino acid sequence has been deduced from a DNA sequence may not even be known. This has created greater interest in the development of methods to predict the tertiary structures of proteins. The a priori prediction of a protein's structure from its amino acid sequence is not yet possible. However, since proteins with similar amino acid sequences are observed to have similar three-dimensional structures, it is possible to use an analogy with a protein of known structure to draw some conclusions about the structure and properties of an uncharacterized protein. The process of predicting the tertiary structure of a protein relies very much upon computer modeling and analysis of the structure. The prediction of the structure of the bacteriophage 434 cro repressor is used as an example illustrating current procedures. |
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Keywords: | Molecular modeling Repressor structure Protein structure prediction |
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