Discovery of novel inhibitors of <Emphasis Type="Italic">Streptococcus pneumoniae</Emphasis> based on the virtual screening with the homology-modeled structure of histidine kinase (VicK) |
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| Authors: | Nan Li Fei Wang Siqiang Niu Ju Cao Kaifeng Wu Youqiang Li Nanlin Yin Xuemei Zhang Weiliang Zhu Yibing Yin |
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| Institution: | (1) Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Faculty of Laboratory Medicine, Chongqing Medical University, 400016 Chongqing, PR China;(2) Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Material Medical, Graduate School of Chinese Academy of Sciences, 201203 Shanghai, PR China |
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| Abstract: | Background Due to the widespread abusage of antibiotics, antibiotic-resistance in Streptococcus pneumoniae (S. pneumoniae) has been increasing quickly in recent years, and it is obviously urgent to develop new types of antibiotics. Two-component
systems (TCSs) are the major signal transduction pathways in bacteria and have emerged as potential targets for antibacterial
drugs. Among the 13 pairs of TCSs proteins presenting in S. pneumoniae, VicR/K is the unique one essential for bacterium growth, and block agents to which, if can be found, may be developed as
effective antibiotics against S. pneumoniae infection. |
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