Tissue-specific cytokine release from human extra-placental membranes stimulated by lipopolysaccharide in a two-compartment tissue culture system |
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| Authors: | Natalie W Thiex Mark C Chames Rita K Loch-Caruso |
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| Affiliation: | (1) Department of Environmental Health Sciences, School of Public Health, The University of Michigan, 1415 Washington Heights, 48109-2029 Ann Arbor, MI, USA;(2) Department of Obstetrics and Gynecology, University of Michigan Health System, F4835 Mott Hospital, 48109-0264 Ann Arbor, MI, USA |
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| Abstract: | Background The extra-placental gestational membranes secrete cytokines in response to bacteria and other infectious agents, with potentially adverse consequences for pregnancy. The present study used lipopolysaccharide (LPS) as a prototype endotoxin to investigate the pattern of stimulated cytokine release from the amniotic and choriodecidual sides of full-thickness human gestational membranes in a two-compartment tissue culture system. |
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