Three-point linkage analysis employing C3 and 19cen markers assigns the myotonic dystrophy gene to 19q |
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| Authors: | Ursula Friedrich Han Brunner Dominique Smeets Eric Lambermon Hans-Hilger Ropers |
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| Affiliation: | (1) Institute for Human Genetics, University of Aarhus, Aarhus, Denmark;(2) Department of Human Genetics, Anthropogenetic Institute, Catholic University of Nijmegen, Geert Grooteplein Zuid 20, NL-6525 GA Nijmegen, The Netherlands |
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| Abstract: | Summary In seven large families with myotonic dystrophy (DM) comprising 102 individuals, linkage studies were perfermed employing restriction fragment length polymorphisms in the complement component 3 gene and the 19cen C banding heteromorphism as genetic markers. Three-point linkage analysis excludes DM from the 19cen-C3 segment and strongly supports its assignment to the proximal long arm of chromosome 19. |
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