In vitro cytotoxicity of heavy metals,acrylamide, and organotin salts to neural cells and fibroblasts |
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| Authors: | Ellen Borenfreund Harvey Babich |
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| Affiliation: | (1) Laboratory Animal Research Center, Rockefeller University, New York, New York;(2) Laboratory Animal Research Center, Rockefeller University, 1230 York Avenue, 10021 New York, NY |
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| Abstract: | The cytotoxicity of neurotoxic agents was determined for a series of brain-derived cell types and compared with their toxic effects on BALB/c 3T3 fibroblasts, using the neutral red assay. Ranking of toxicants according to their potencies was the same for all cells tested and was in the order of methylmercury>cadmium> mercury>zinc>acrylamide. For a series of di- and triorganotins the ranking order was dibutyl>diphenyl>dibenzyl>diproyl> diethyl>dimethyltin and triphenyl>tribenzyl>trimethyltin, respectively. The test was sensitive enough to detect structure activity relationships between the degree of toxicity and the hydrophobic characteristics of the agents tested.Abbreviations Be2Sn dibenzyltin dichloride - Be3Sn triphenyltin dichloride - Bu2Sn dibutyltin dichloride - CdCl2 cadmium chloride - CH3HgCl methylmercuric chloride - DMEM Dulbecco's Modified Eagle's Medium - Et2Sn diethyltin dichloride - FBS fetal bovine serum - HgCl2 mercuric chloride - Me2Sn dimethyltin dichloride - Me3Sn trimethyltin hydroxide - Phe2Sn diphenyltin dichloride - Phe3Sn triphenyltin hydroxide - Pr2Sn dipropyltin dichloride - ZnCl2 zinc chloride |
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| Keywords: | fibroblasts in vitro neural cells neurotoxic agents |
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