The herbal medicines Saireito and Boiogito improve the hypertension of pre-eclamptic rats induced by N-Nitro-l-arginine methyl ester |
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Authors: | Hisato Takei Yoichiro Nakai Naoko Hattori Masahiro Yamamoto Shuichi Takeda Masako Yamamoto Kazuyoshi Arishima |
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Affiliation: | Pharmacology Research Department, Tsumura Research Institute, Tsumura and Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan. takei_hisato@mail.tsumura.co.jp |
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Abstract: | The chronic inhibition of nitric oxide (NO) synthesis with N(omega)-Nitro-L-arginine methyl ester (L-NAME) induces a pre-eclampsia-like syndrome including hypertension in pregnant rats. We tested the traditional herbal medicines Saireito (SR) and Boiogito (BO), which have been used clinically for the treatment of pre-eclampsia, in this model. L-NAME was infused subcutaneously into pregnant rats from gestational day 14 (G14). SR and BO (both at 1, 2g/kg) were administered by gavage from G14 to G20. Systolic blood pressure was measured on G19. SR and BO (both at 1, 2g/kg) inhibited L-NAME-induced hypertension. SR was effective in both pregnant and non-pregnant rats while BO was effective only in pregnant rats. BO increased blood levels of CGRP and decreased levels of endothelin-1; both are known to play important roles in regulation of blood pressure in pre-eclampsia. SR and BO may be beneficial for the treatment and prevention of hypertension in pre-eclampsia. |
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Keywords: | Saireito Boiogito Nω -Nitro- smCaps" >l-arginine-methyl ester Hypertension Pregnancy |
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