卵母细胞在哺乳动物卵巢排卵过程中的决定性作用

哺乳动物卵巢排卵是一个复杂的调控过程。卵泡成熟破裂后，卵母细胞从卵巢中排出。卵泡细胞感受排卵刺激，并诱导卵母细胞减数分裂的恢复及其随后的释放。卵母细胞及其周围颗粒细胞的旁分泌在对此起关键性作用，其中卵母细胞对其释放具有决定性作用。作者先前已经阐述过颗粒细胞在哺乳动物卵巢排卵过程中的调控作用，该文将从卵母细胞的发育及其调控角度重点阐明其在排卵过程中的决定作用，旨在进一步理解哺乳动物卵巢的排卵过程，同时为不孕不育等卵巢疾病的治疗提供重要的研究方向和理论基础。

Decisive Effects of Oocytes on the Ovulatory Process in the Mammalian Ovary

Ovulation is a complex regulating process in the mammalian ovary. This important physiological process includes oocytes released from the ovary with follicle ruptures after the oocyte maturation. Follicular cells sense the ovulatory stimulus and induce the resumption of meiosis and subsequent release of oocytes. Paracrine be- tween the oocyte and its surrounding granulosa cells plays a critical role in this process, and the oocyte has the deci- sive effect on its release. Previously, we have described the regulatory effect of granulosa cells on ovarian ovulation in mammals. In the present paper, we clarify the decisive effects of oocytes on the ovulatory process in mammalian ovaries from the perspective of the oocyte development and its regulation, in order to further understand ovulation and provide the important research direction and theoretical basis for the treatment of ovarian diseases, such as infertility.