Necator americanus: maintenance through one hundred generations in golden hamsters (Mesocricetus auratus). I. Host sex-associated differences in hookworm burden and fecundity |
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Authors: | Jian Xue Sen Liu Hui-Qin Qiang Hai-Nan Ren Tie-Hua Li Hai-Chou Xue Hotez Peter J Shu-Hua Xiao |
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Institution: | Institute of Parasitic Diseases, Chinese Centers for Disease Control and Prevention, 207 Rui Jin Er Lu, Shanghai 200025, PR China. |
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Abstract: | The human hookworm Necator americanus was maintained through one hundred generations in the golden hamster (Mesocricetus auratus). The parasite strain employed here was ultimately adapted to hamsters without the requirement for exogenous steroids or other immunosuppressive agents. Moreover, there was no requirement to use neonatal hamsters--successful infections were obtained in 9- to 10-week-old hamsters infected subcutaneously with 250 hookworm larvae. This unique adaptation of N. americanus to hamsters permits its use for purposes of anthelminthic drug and vaccine development. |
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