| 微RNA miR-29与人类疾病 |
| |
| 引用本文： | 黄昌发,刘小珊.微RNA miR-29与人类疾病[J].生命的化学,2010(2). |
| |
| 作者姓名： | 黄昌发 刘小珊 |
| |
| 作者单位： | 汕头大学医学院生物化学教研室; |
| |
| 摘 要： | 人类微RNA miR-29包括miR-29a、miR-29b1、miR-29b2和miR-29c。miR-29在胚胎期组织不表达或低表达,而在生物体成熟组织细胞中广泛表达。实验证实的miR-29作用的靶点包括DNMT3A/3B、YY1、Mcl-1、BACE1以及HIV-1病毒等。miR-29与人类疾病密切相关,miR-29在多种肿瘤细胞、心肌梗塞与散发性阿尔茨海默病等病变组织细胞中表达受抑。本文就miR-29基因结构、基因表达与调控、生物学功能以及与疾病发生相关性作一综述。
|
| 关 键 词： | miR-29 基因表达与调控 人类疾病 |
miR-29 and human diseases |
| |
| Chang-Fa Huang,Xiao-Shan Liu.miR-29 and human diseases[J].Chemistry of Life,2010(2). |
| |
| Authors: | Chang-Fa Huang Xiao-Shan Liu |
| |
| Institution: | Chang-Fa Huang,Xiao-Shan Liu Department of Biochemistry,Medical School,Shantou University,Shantou 515041,China |
| |
| Abstract: | hsa-miR-29 are composed of miR-29a,miR-29b1,miR-29b2,and miR-29c.The expression of miR-29 is low or absent in embryonic tissues.miR-29 are reported to be strongly expressed in adult body cells.The identified targets of miR-29 contain DNMT3A/3B,Mcl-1,BACE1,and HIV-1 virus,etc.miR-29 are highly associated with human diseases as the expression of miR-29s was found to be significantly down-regulated in different types of human cancer cells and related tissues with various diseases such as myocardial infarction ... |
| |
| Keywords: | miR-29 gene expression and regulation human disease |
| 本文献已被 CNKI 等数据库收录！ |
|
