Antifungal activity of nontraditional antifungal agents |
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Authors: | William R Judd Craig A Martin |
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Institution: | (1) UK HealthCare Pharmacy Services, Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, 800 Rose Street, H110, Lexington, KY 40536, USA |
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Abstract: | Invasive fungal infections are becoming increasingly important in the management of critically ill and immunocompromised patients.
As organ and stem cell transplantation becomes more prominent and immune therapies are employed for diseases such as rheumatoid
arthritis and plaque psoriasis, the population of patients at risk continues to grow. Many invasive fungal infections are
associated with extremely high mortality rates. Antifungal options are limited and novel therapies are intriguing as we attempt
to improve patient outcomes and preserve the antifungal armamentarium. Many other classes of pharmaceuticals typically seen
as non-antifungal do in fact have significant antifungal activity. Prominent among these are calcineurin inhibitors, antiarrhythmics,
antidepressants, antibacterials, and others. Some have activity alone and some augment the activity of conventional antifungals.
Unfortunately, clinical data are lacking for most of these agents and their role in therapy remains undefined. This review
focuses on several representative non-antifungal agents with antifungal activity. |
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Keywords: | |
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