Calcium signaling in the nucleus |
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Authors: | Gomes Dawidson A Leite M Fatima Bennett Anton M Nathanson Michael H |
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Institution: | Department of Pharmacology, Federal University of Minas Gerais, Belo Horizonte, Brazil. |
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Abstract: | Cytosolic Ca(2+) is a versatile secondary messenger that regulates a wide range of cellular activities. In the past decade, evidence has accumulated that free Ca(2+) within the nucleus also plays an important messenger function. Here we review the mechanisms and effects of Ca(2+) signals within the nucleus. In particular, evidence is reviewed that the nucleus contains the machinery necessary for production of inositol 1,4,5-trisphosphate and for inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release. The role of Ca(2+) signals within the nucleus is discussed including regulation of such critical cell functions as gene expression, activation of kinases, and permeability of nuclear pores. |
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