<Emphasis Type="Italic">Symbiobacterium</Emphasis> Lost Carbonic Anhydrase in the Course of Evolution |
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Authors: | Hiromi Nishida Teruhiko Beppu Kenji Ueda |
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Institution: | (1) Agricultural Bioinformatics Research Unit, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan;(2) Life Science Research Center, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252-8510, Japan |
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Abstract: | Recent genetic studies have elucidated that carbonic anhydrase (CA; EC 4.2.1.1), a ubiquitous enzyme catalyzing interconversion
between CO2 and bicarbonate, is essential for microbial growth under ambient air but not under high-CO2 air. The irregular distribution of the phylogenetically distinct types of CA in the prokaryotic genome suggests its complex
evolutionary history in prokaryotes. This paper deals with the genetic defect of CA in Symbiobacterium thermophilum, a syntrophic bacterium that effectively grows on CO2 generated by other bacteria. Phylogenetic analysis based on 31 ribosomal protein sequences demonstrated the affiliation of
Symbiobacterium with the class Clostridia with 100% bootstrap support. The phylogeny of β- and γ-type CA distributed among Clostridia supported
the view that S. thermophilum and several related organisms lost this enzyme during the course of evolution. The loss of CA could be based on the availability
of a high level of CO2 in their living environments.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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Keywords: | Carbonic anhydrase Symbiobacterium Clostridia Ribosomal proteins Syntrophic bacteria |
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